The synthesis of 3,4-benzpyrene-5-C14 and of 2-acetylaminofluorene-9-C14.
نویسندگان
چکیده
منابع مشابه
The metabolism in vitro of fluorene derivatives by rat liver: hydroxylation and protein binding.
Previous studies in vitro of the metabolism of the carcinogen 2-acetylaminofluorene (AAF) by rat liver slices indicated that the compound is subject to deacetylation, hydroxylation, and protein binding (1, 2). Protein binding of carcinogens of diverse chemical structure by the susceptible tissue appears t.o be a generalized phenomenon and, in several instances, there is a good correlation betwe...
متن کاملSpectrometric studies of the persistence of fluorescent derivatives of carcinogens in mice.
Many attempts have been made to trace the path by which carcinogens are metabolized, with the hope that this may shed some light on the mecha nism of carcinogenesis. Current literature still con tains conflicting evidence on the question of whether the hydrocarbon itself, perhaps in a pro tein complex, or a metabolite is the active carcino genic agent. The work of Peacock et al. (7) sug gests t...
متن کاملOn the in y ivo Protein Binding of l-Hydroxy-2-acetylamino- fluorene-1-C14 in the Rat* CHARLESC. IRVINGAND ROBERTF. WILLIARD
At 24 hours after administration of a single dose of 3-4 mg. of l-hydroxy-2-acetylaminofluorene-1-C14 (1-hydroxy-AAF-l-C14) intraperitoneally to rats, 75 per cent of the dose had been excreted in the urine and feces. About 5 per cent of the injected radioactivity was present in the gastrointestinal contents, and only 1-2 per cent re mained in the tissues of the rat. Radioactivity equivalent to ...
متن کاملOn the in y ivo Protein Binding of l-Hydroxy-2-acetylamino- fluorene-1-C14 in the Rat* CHARLESC. IRVINGAND ROBERTF. WILLIARD
At 24 hours after administration of a single dose of 3-4 mg. of l-hydroxy-2-acetylaminofluorene-1-C14 (1-hydroxy-AAF-l-C14) intraperitoneally to rats, 75 per cent of the dose had been excreted in the urine and feces. About 5 per cent of the injected radioactivity was present in the gastrointestinal contents, and only 1-2 per cent re mained in the tissues of the rat. Radioactivity equivalent to ...
متن کاملStudies on the protein synthesis in poisoning. III. Labeling of pH-5 enzyme with C14-glycine and the inhibition by para chloromercuribenzoate.
The labeling of C14-glycine to pH-5 enzyme, PP32-ATP exchange by pH-5 enzyme, and the inhibitory action of p-chloromercuribenwate were examined. 1) The labeling of C14-glycine to pH-5 enzyme is inhibited by 10-4 mole of PCMB, and this inhibitory effect is reduced by addition of cysteine having 20 mole equivalent of PCMB. 2) The PP32-ATP exchange reaction is also reduced by addition of PCMB and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cancer research
دوره 11 8 شماره
صفحات -
تاریخ انتشار 1951